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High levels of resistance to antibiotics prescribed for UTIs in children

25 Apr 2016Registered users

A meta-analysis has revealed significant levels of resistance to commonly prescribed antibiotics for urinary tract infections (UTI) in children. Resistance rates were highest for ampicillin and lowest for nitrofurantoin. The researchers set out to determine the prevalence of antibiotic resistant E. coli UTIs in children in a primary care setting and to quantify the relationship between prior exposure to antibiotics and subsequent bacterial resistance.

Survivors of childhood cancer at increased risk of autoimmune diseases

25 Jan 2016Paid-up subscribers

A Scandinavian study of survivors of childhood cancer has found a significantly higher incidence of a range of autoimmune disorders compared with matched controls. Using Denmark, Iceland and Sweden’s comprehensive national cancer and hospital episode recording registries 20,361 survivors of cancer diagnosed before the age of 20 were identified. These individuals were matched with 125,794 controls selected from national population registers. The median follow-up was 15 years for survivors and 19 years for controls (range 0-42 years for both).

Enterovirus linked to type 1 diabetes in children

24 Nov 2014Paid-up subscribers

A large retrospective population-based cohort study from Taiwan has added weight to the association between enterovirus infection and onset of type 1 diabetes in childhood.

Macrolides linked to increased risk of infantile hypertrophic pyloric stenosis

22 May 2014Paid-up subscribers

A large and very well organised study from Denmark has shown that there is a significantly increased risk of infantile hypertrophic pyloric stenosis (IHPS) in infants exposed to macrolide antibiotics. Data were collected over 16 years on nearly one million (999,378) singleton liveborn babies. Overall, 30,091 women (3%) took macrolides during pregnancy and 21,557 (2.2%) after birth. A total of 6,591 infants (0.6%) were given macrolide treatment directly.

Do CT scans in childhood raise cancer risk?

25 Jul 2013Paid-up subscribers

Undergoing CT scans during childhood is associated with a small but significant risk of developing cancer, a large data linkage study from Australia has found. The absolute excess incidence rate for all cancers combined was 9.38 per 100,000 person-years at risk after nearly ten years’ follow-up.

Cryptorchidism raises risk of testicular cancer later on

28 Jan 2013Paid-up subscribers

Boys with isolated cryptorchidism have a three-fold increased risk of developing testicular cancer later in life, a meta-analysis published in Archives of Disease in Childhood has found.

Children of older mothers have better health outcomes

12 Dec 2012Paid-up subscribers

Older maternal age is associated with better health and development in young children, a large observational study from the UK has found.

Early diagnosis is key in autism

01 Jun 2007Paid-up subscribers

Paediatrics