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Depression in midlife does not raise risk of dementia

23 Oct 2017Registered users

Depression may be a prodromal feature of, rather than a risk factor for, dementia, a UK prospective cohort study has found. A total of 10,308 participants (6,895 men) in the Whitehall ll study, aged 35-55 at recruitment, were followed up between 1985 and 2015. 

Moderate alcohol consumption may affect cognitive function

22 Sep 2017Registered users

Even moderate alcohol consumption, compared with abstinence, may raise the risk of hippocampal atrophy and faster decline in lexical fluency, an analysis of data from the Whitehall ll study has found.

Incretin-based diabetes therapy not associated with increased mortality

28 Jul 2017Registered users

A recent meta-analysis, published in the BMJ, has shown no increase in all cause mortality in patients with type 2 diabetes using incretin-based treatments i.e. GLP-1 agonists and DPP-4 inhibitors.

High maternal BMI linked to increasing risk of congenital abnormalities

28 Jul 2017Registered users

The risk of major congenital malformations in infants rises with maternal overweight and degree of obesity, a large study from Sweden has shown.

Should lithium treatment be continued during pregnancy?

28 Jul 2017Registered users

Women who take lithium during early pregnancy have a slightly increased risk of giving birth to a child with a cardiac malformation, a large retrospective cohort study from the USA has found.

Risk of suicide in university students double that of graduates

22 Jun 2017Registered users

Compared with those who have completed university education, university students are more than twice as likely to commit suicide, a Swedish study has found.

Termination of pregnancy via telemedicine service safe and effective

22 Jun 2017Registered users

Women using an online telemedicine service for medical termination of pregnancy (MTOP) reported good outcomes, a study has found.Women using an online telemedicine service for MTOP reported good outcomes, a study has found. The study authors analysed data on all women from the Republic of Ireland and Northern Ireland who contacted the Women on Web telemedicine helpdesk, between January 2010 and December 2012. (In both countries termination is not available through the formal healthcare system except in restricted circumstances).

Gambling linked to mental health problems

22 Jun 2017Registered users

Patients with depression and those who drink at risky levels are more than twice as likely to report gambling problems, a UK primary care study has shown.

Drinking tea every day may lower risk of ischaemic heart disease

22 Jun 2017Registered users

Daily tea consumption was associated with an 8% relative risk reduction in ischaemic heart disease and a 10% relative risk reduction in major cardiac events, in a large prospective study from China.

Chlamydia and HIV testing for young people in primary care

22 Jun 2017Registered users

Young men and women would be happy to be offered chlamydia screening, contraception and HIV tests from GPs, a UK study has shown.

Gestational diabetes is on the increase

23 May 2017Paid-up subscribers

The prevalence of gestational diabetes mellitus (GDM) has been increasing over the past three decades, a large retrospective cohort study from the US has shown.

Heavy drinkers and teetotallers at increased risk of wide range of cardiovascular diseases

23 May 2017Registered users

Both high levels of alcohol consumption and abstinence raise the risk of a broad spectrum of cardiovascular disorders, a UK study has shown.

Insulin pumps vs multiple injections in adults with type 1 diabetes

23 May 2017Registered users

A randomised controlled trial comparing insulin pump use with multiple daily injections suggests that when patients are engaged with intensive self-management, insulin pump therapy may not add significant extra benefits in adults.

Non-major bleeds less frequent in AF patients on apixaban

23 May 2017Paid-up subscribers

Non-major bleeding was substantially less in patients on apixaban compared with those on warfarin in the Apixaban for Reduction in Stroke and other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial. 

Gene variants associated with increased risk of congenital heart defects with SSRI use

24 Apr 2017Paid-up subscribers

Common variants in genes related to folic acid, homocysteine and glutathione/transsulfuration metabolic pathways are associated with an increased risk of congenital heart disease in the offspring of women who take SSRIs in the periconceptual period, a US case control study has found.

Benzodiazepine and opioid co-prescribing raises risk of opioid overdose

24 Apr 2017Paid-up subscribers

Stopping concurrent benzodiazepine and opioid prescribing could reduce the risk of inpatient admissions for opioid overdose and attendance at emergency departments by 15%, a study from the US has found.

Uncomplicated menorrhagia can be effectively managed in primary care

24 Apr 2017Paid-up subscribers

A UK primary care study comparing the use of the levonorgestrel-IUS (LNG-IUS) with usual medical treatments for heavy menstrual bleeding (HMB) showed both to have very good outcomes.

Stress echo has good diagnostic accuracy in elderly patients

24 Apr 2017Paid-up subscribers

Stress echocardiography is a safe and effective first-line test for suspected coronary artery disease in patients over 80, a UK study, published in Heart, has found.

Early catheter ablation improves outcomes in paroxysmal AF

22 Mar 2017Registered users

Patients with paroxysmal atrial fibrillation (AF) treated with catheter ablation first line showed significantly better improvement than those treated initially with drug therapy in a multicentre, randomised, unblinded trial. The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation (MANTRA-PAF) trial compared radiofrequency catheter ablation with antiarrhythmic drug therapy as first-line treatment for paroxysmal AF.

GP vs clinic care for people living with HIV

22 Mar 2017Registered users

Around 60% of people living with HIV would choose GP care in preference to an HIV clinic, a UK study has found.

Risk factors for antepartum stillbirth

22 Mar 2017Paid-up subscribers

Antepartum stillbirth is a complex syndrome associated with a range of risk factors, a prospective observational study has concluded.

Homelessness is an independent risk factor for mortality

01 Jun 2009Registered users

Although the higher mortality risk associated with homelessness can partly be explained by an increased prevalence of morbidity, homelessness itself confers an additional risk, a retrospective cohort study has shown. 'In this study, homelessness itself has been shown to be an independent risk factor for the high mortality seen in this group. In addition to interventions addressing morbidity in homeless people, intensive targeted social interventions directed to homelessness itself may be needed to lower mortality in this highly disadvantaged social group.'

Stroke risk similar in paroxysmal and sustained AF

23 Jan 2008Registered users

Current guidelines advise treating paroxysmal AF in the same way as sustained AF but the evidence is weak, with only one retrospective analysis comparing the risk of stroke in patients with paroxysmal AF vs chronic AF (analysis of the SPAF trials, performed 15 years ago and limited to patients treated with aspirin). The ACTIVE W trial showed that warfarin is more effective than aspirin plus clopidogrel for the prevention of vascular events (stroke, embolism, MI and vascular death) in patients with AF. A recent substudy of this trial looked at the risk of stroke in 1,202 patients with paroxysmal AF compared with 5,495 with sustained AF, and the effectiveness of thromboprophylaxis in these patients. ' This substudy has shown that the risk of stroke is similar, irrespective of whether AF is paroxysmal or sustained, and that anticoagulation therapy is equally effective in both groups. Other factors, such as age and cardiovascular comorbidity, remain central to the ultimate choice of thromboprophylaxis in these patients.'