Sex differences remain in the prevalence and treatment of CVD risk factors

22 Mar 2021Registered users

Differences persist in the prevalence, treatment and control of risk factors for cardiovascular disease between men and women, an analysis of data from the Health Survey for England 2012-2017 has found. Men were more likely to have one or more risk factors than women. However, figures for both treatment and control of dyslipidaemia were significantly lower in women than men.

Food anaphylaxis admissions rise but case fatality rates fall

22 Mar 2021Registered users

Although hospital admissions for food anaphylaxis increased over the past 20 years in the UK the case fatality rate more than halved, an analysis of national data has shown.

Are prescription opioids safe to use in pregnancy?

22 Mar 2021Registered users

Prescription opioids used in early pregnancy are not associated with a substantial increase in the risk of most congenital malformations, although a small increase in the risk of oral clefts associated with their use is possible, a large US study has found.

Which drugs should be used first line for hypertension?

21 Feb 2021Registered users

Tailoring choice of antihypertensives to the patient rather than using strict age criteria might be more beneficial, the authors of a UK observational cohort study suggest.

Preterm birth associated with shorter life span

21 Feb 2021Registered users

Individuals born even slightly prematurely have an increased risk of early death in adult life, a Nordic population-based study has found.

Increased risk of attempted suicide in young problem gamblers

21 Feb 2021Registered users

Men and women, under the age of 25, with problem gambling are at increased risk of trying to take their own lives, a UK study has found.

Prematurity associated with higher hospital admission rates in childhood

25 Jan 2021Registered users

Children born preterm, even at 38 and 39 weeks’ gestation, have increased hospital admission rates in the first ten years of life, a large population-based study has found.

Which treatments are effective for maintaining abstinence from alcohol in primary care?

25 Jan 2021Registered users

Acamprosate was the only intervention with evidence that it was better than placebo in maintaining alcohol abstinence for up to 12 months, following detoxification, in a network meta-analysis.

Childhood cancer survivors at increased risk of cardiac ischaemia

25 Jan 2021Registered users

Children who have survived cancer, particularly those treated with chemotherapy and/or radiotherapy, have a higher risk of adverse cardiac events later on, a pan-European study has found.

Loneliness associated with increased risk of type 2 diabetes

21 Dec 2020

A study based on the English Longitudinal Study of Ageing (ELSA) suggests that loneliness is an independent risk factor for diabetes.

Can a hot bath a day keep the cardiologist away?

21 Dec 2020Registered users

Taking a hot bath every day or most days may lower the risk of cardiovascular disease (CVD), a study from Japan has suggested.

Relationship structure and sexual health

21 Dec 2020Registered users

Consensually nonmonogamous partnerships, including open relationships, comprise a substantial proportion of sexual relationships in the USA, a national population-based survey has concluded. It is important to be non-judgemental when eliciting sexual histories, to discuss risks and offer the right tests to the right people to minimise STI/HIV transmission.

HPV vaccination lowers risk of invasive cervical cancer

24 Nov 2020Registered users

Introduction of the quadrivalent human papilloma virus (HPV) vaccination programme in girls and young women in Sweden has led to a substantially reduced risk of invasive cervical cancer at population level, a national study has shown.

Smokers’ dependence on cigarettes has decreased over the past decade

24 Nov 2020Registered users

Between 2008 and 2017 smokers appear to have become less dependent on cigarettes but also less likely to try to quit or cut down. For those who tried to quit, fewer used behavioural support and more used pharmacological support, a study has found.

Long-term PPI use associated with increased risk of type 2 diabetes

24 Nov 2020Registered users

Regular use of proton pump inhibitors (PPIs) increased the risk of type 2 diabetes in a cohort analysis of three large American population studies. The risk increased with longer duration of use.

Corticosteroid therapy for asthma raises risk of osteoporosis and fragility fractures

27 Oct 2020Registered users

Use of oral or inhaled corticosteroids appears to be an independent risk factor for osteoporosis and fragility fractures in patients with asthma, a UK population-based study has found.

Prediabetes associated with increased risk of CVD and all-cause mortality

27 Oct 2020Registered users

A meta-analysis has shown an association between prediabetes and raised risk of all-cause mortality and incident cardiovascular disease in the general population as well as patients with atherosclerotic heart disease.

Engagement with HCV therapy linked to lower deaths from all causes in injecting drug users

27 Oct 2020Registered users

Engagement with hepatitis C treatment by people who inject drugs is associated with a lower risk of all-cause mortality and drug-related death, a study set in Scotland has found.

Nausea may affect adherence to varenicline

24 Sep 2020Registered users

Nausea during the first few weeks of varenicline therapy may reduce adherence, a study from North America has found. The authors analysed data on 870 adults receiving varenicline in two smoking cessation trials conducted at multiple sites in Canada and the USA.

Is air pollution associated with onset of asthma in childhood?

24 Sep 2020Registered users

A nationwide case-control study from Denmark has strengthened the evidence that parental asthma and smoking in pregnancy are risk factors for onset of asthma and persistent wheezing in children. The results also suggest that exposure to ambient small particles < 2.5 µm (PM2.5) may be a potential risk factor. However, this finding needs to be substantiated in future studies, the authors say.

Diet rich in whole grain foods may lower risk of diabetes

24 Sep 2020Registered users

Higher consumption of total whole grain foods, such as oatmeal, dark bread, brown rice or whole grain cereals can reduce the risk of developing type 2 diabetes, analysis of data from three large prospective cohort studies in the USA has shown.

Loneliness a risk factor for cardiovascular disease

24 Sep 2020Registered users

Loneliness but not social isolation appears to be an independent risk factor for cardiovascular disease, an analysis of data from the English Longitudinal Study of Ageing suggests.

Lifestyle intervention reduces risk factors in older patients with coronary artery disease

24 Jul 2020Registered users

Patients aged 65 years and over with coronary artery disease benefitted at least as much as younger patients in improving lifestyle risk factors in a community-based trial from the Netherlands. Older patients were more likely to achieve the weight loss target and stop smoking.

Asthma persisting from childhood to adulthood presents a distinct phenotype

24 Jul 2020Registered users

Asthma that starts in childhood and persists throughout adult life tends to be more severe and is associated with poorer lung function compared with adult-onset asthma, a study from Japan has concluded. The difference in clinical characteristics points to a distinct phenotype.

Evaluating therapies for depression in children and adolescents

24 Jul 2020Registered users

Fluoxetine, either alone or in combination with cognitive behaviour therapy, appears to be the most effective treatment for children and adolescents with moderate to severe depression, a systematic review and network meta-analysis has concluded. NICE recommends that antidepressants should not be initiated in primary care.

Patient safety incidents in opioid substitution therapy analysed

24 Jul 2020Registered users

Errors in prescribing, supervised or non-supervised dispensing, and monitoring and communication were responsible for patient safety incidents in opioid substitution treatment, a study from England and Wales has shown.

Healthy lifestyle associated with longer life expectancy free of diabetes

22 Jun 2020Paid-up subscribers

A large cohort study has demonstrated that a healthy lifestyle in midlife can increase life expectancy free of type 2 diabetes, as well as cardiovascular disease (CVD) and cancer.

Siblings of infants with sudden unexpected death at increased risk

22 Jun 2020Paid-up subscribers

An observational study using clinical case records has found a ten-fold increased risk of sudden unexpected death in infancy (SUDI) in siblings of SUDI cases.

Primary care intervention increases uptake of HCV testing

22 Jun 2020Paid-up subscribers

An electronic algorithm integrated with primary care clinical database systems achieved a modest increase in hepatitis C (HCV) case finding, a UK general practice-based study has found.

E-cigarette pilot study helps smokers quit

22 Jun 2020Paid-up subscribers

More than a third of smokers who completed a pilot study of e-cigarettes as a smoking cessation aid quit smoking.

Increased risk of fatal overdose or suicide associated with stopping opioids

25 May 2020Registered users

Ceasing treatment with opioids is associated with an increased risk of death from overdose and suicide, an observational study from the United States has found.

Emollients do not prevent eczema in infancy

25 May 2020Paid-up subscribers

Daily emollient use for the first 12 months of life did not protect against the development of eczema in high-risk children, a UK study has found. Infants born at full term were recruited to a randomised controlled trial carried out at 12 hospitals and four primary care sites across the UK between 2014 and 2016. All the infants were deemed at high risk of developing eczema because of a family history of atopic disease i.e. at least one first-degree relative with parent reported eczema, allergic rhinitis, or asthma diagnosed by a doctor.

Abdominal obesity post MI raises risk of recurrent MI or stroke

25 May 2020Paid-up subscribers

Abdominal obesity is an independent risk factor for a further myocardial infarction (MI) or stroke in patients who have already suffered a first MI, an observational cohort study from Sweden has shown. A total of 22,882 MI patients from the SWEDEHEART registry (Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies) were recruited to the study.

SGLT2 inhibitors reduce risk of serious renal events

25 May 2020Paid-up subscribers

A Scandinavian observational study has shown that sodium-glucose co-transporter 2 (SGLT2) inhibitors are associated with a significant reduction in serious renal events compared with dipeptidyl peptidase-4 (DPP-4) inhibitors. The study used Scandinavian disease registry data to compare population outcomes in the general diabetic population rather than selected groups of high-risk patients.

Exercise improves function and mortality rates in older patients following ACS

23 Apr 2020Paid-up subscribers

A largely home-based exercise intervention improved grip strength, mobility, daily activities and quality of life in older patients after acute coronary syndrome, an Italian study has shown. Hospitalisation and death rates were also reduced by the intervention. A total of 235 patients, median age 76 years, range 73-81 years, were recruited to the trial conducted at three sites in Italy. They were randomised one month after their ACS event to the exercise or control group. All had reduced physical performance defined by the short physical performance battery with scores of 4-9.

Smoking in pregnancy increases fracture risk in infants

23 Apr 2020Paid-up subscribers

Intrauterine exposure to maternal smoking is associated with an increased risk of fractures in the first year of life, a national cohort study from Sweden has found. The study cohort comprised 1,680,307 live born singletons in Sweden, born between 1 January 1983 and 31 December 2000, followed up until 31 December 2014.

Substance use disorder raises risk of treatment resistant depression

23 Apr 2020Paid-up subscribers

Recent or current substance use disorder is associated with treatment resistance in patients who receive prescription treatment for depression, a nested case control study has found.

Exercise can improve functional status in diabetic neuropathy

24 Mar 2020Paid-up subscribers

Physiotherapy to improve ankle strength and balance produced sustained improvements in functional status in patients with diabetic peripheral neuropathy, in a study from Singapore.

Weight gain associated with accelerated lung function decline

24 Mar 2020Paid-up subscribers

Adults who put on weight over a 20-year period had a more rapid decline in FVC and FEV1, a large international population-based study has shown. However, weight loss was found to attenuate the decline.

LARC uptake increases in young women

24 Mar 2020Paid-up subscribers

There has been a significant increase in the use of long-acting reversible contraception in women under 25 over the past decade, a national survey has found. However, condoms and the oral contraceptive pill are still the most commonly used methods.

Homelessness is an independent risk factor for mortality

01 Jun 2009Registered users

Although the higher mortality risk associated with homelessness can partly be explained by an increased prevalence of morbidity, homelessness itself confers an additional risk, a retrospective cohort study has shown. 'In this study, homelessness itself has been shown to be an independent risk factor for the high mortality seen in this group. In addition to interventions addressing morbidity in homeless people, intensive targeted social interventions directed to homelessness itself may be needed to lower mortality in this highly disadvantaged social group.'

Stroke risk similar in paroxysmal and sustained AF

23 Jan 2008Registered users

Current guidelines advise treating paroxysmal AF in the same way as sustained AF but the evidence is weak, with only one retrospective analysis comparing the risk of stroke in patients with paroxysmal AF vs chronic AF (analysis of the SPAF trials, performed 15 years ago and limited to patients treated with aspirin). The ACTIVE W trial showed that warfarin is more effective than aspirin plus clopidogrel for the prevention of vascular events (stroke, embolism, MI and vascular death) in patients with AF. A recent substudy of this trial looked at the risk of stroke in 1,202 patients with paroxysmal AF compared with 5,495 with sustained AF, and the effectiveness of thromboprophylaxis in these patients. ' This substudy has shown that the risk of stroke is similar, irrespective of whether AF is paroxysmal or sustained, and that anticoagulation therapy is equally effective in both groups. Other factors, such as age and cardiovascular comorbidity, remain central to the ultimate choice of thromboprophylaxis in these patients.'