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Bundle branch block an indicator of heart failure risk

25 Sep 2019Paid-up subscribers

Opportunistic finding of bundle branch block (BBB) in primary care patients without major cardiovascular disease should be considered a warning of future heart failure, a retrospective cohort study from Denmark concludes.

Many smokers and former smokers have misconceptions about nicotine

25 Sep 2019Paid-up subscribers

Nearly 40% of smokers and former smokers believe it is the nicotine in cigarettes that causes cancer, a UK study has found.

Omega-3 fatty acid supplements do not prevent or improve type 2 diabetes

25 Sep 2019Paid-up subscribers

Supplementary long chain polyunsaturated fatty acids (PUFA) such as omega-3 have no effect on the prevention of diabetes or on glucose metabolism, a large meta-analysis commissioned by the World Health Organization (WHO) has found.

Lack of legacy effect from tight glycaemic control in type 2 diabetes

07 Aug 2019Paid-up subscribers

Adults with type 2 diabetes who had received intensive glucose lowering therapy for nearly six years had a lower risk of cardiovascular events than those who received standard therapy only during the prolonged period in which the HbA1C curves were separated, a study from the US has found. There was no evidence of a legacy effect or a mortality benefit with intensive glucose control 15 years after commencement of the study.

Gabapentinoids may increase risk of suicidal behaviour in young patients

07 Aug 2019Paid-up subscribers

A large Swedish study has suggested that gabapentinoid medications are associated with an increased risk of suicidal behaviour and unintentional overdose in adolescents and young adults.

How does weight change affect risk of atrial fibrillation?

07 Aug 2019Paid-up subscribers

Putting on weight appears to raise the risk of developing atrial fibrillation (AF), a meta-analysis  by investigators in Oxford, UK, has concluded. However, no clear evidence emerged as to whether weight loss reduces the risk.

High levels of cardiorespiratory fitness associated with reduced risk of COPD

07 Aug 2019Paid-up subscribers

Good cardiorespiratory fitness in midlife may lower the risk of developing and dying from COPD, a prospective cohort study from Denmark has found.

Antiretroviral treatment in gay men minimises risk of HIV transmission

24 Jun 2019Registered users

There is effectively zero risk of HIV transmission in gay men through condomless sex when HIV viral load is adequately suppressed, the findings of the PARTNER2 study, published in the Lancet, suggest.

Benefits of quitting smoking outweigh the risks of weight gain

24 Jun 2019Paid-up subscribers

The cardiovascular and overall mortality benefits of stopping smoking far outweigh the risks of weight gain and acquiring type 2 diabetes, a study from the United States has shown.

Controlling risk factors in type 2 diabetes reduces excess risk

24 Jun 2019Paid-up subscribers

Patients with type 2 diabetes who have well controlled risk factors have little or no excess risk of stroke, myocardial infarction or death, a retrospective cohort study has found.

Tramadol associated with longer use of opioids after surgery

24 Jun 2019Paid-up subscribers

A study from the United States has found that patients prescribed tramadol for postoperative pain have a higher risk of prolonged opioid use relative to those given other short-acting opioids.

Do 5 alpha-reductase inhibitors raise the risk of type 2 diabetes?

22 May 2019Registered users

Finasteride and dutasteride appear to be associated with a modest increase in the risk of developing type 2 diabetes, according to the findings of a retrospective cohort study.

Does paternal age affect perinatal outcomes?

22 May 2019Paid-up subscribers

A retrospective population based cohort study from the United States has found a modest correlation between older paternal age and adverse perinatal outcomes.

Sitting time linked to raised mortality risk in inactive adults

22 May 2019Paid-up subscribers

Sitting for long periods is associated with an increased risk of all cause and cardiovascular disease (CVD) mortality among the least physically active adults. However, moderate to vigorous physical activity equivalent to public health recommendations can attenuate or effectively eliminate such associations, a study from Australia has found.

Adolescents face barriers to accessing sexual health information online

22 May 2019Paid-up subscribers

Teenagers are reticent to search for sexual health information online, a small qualitative study has found.

Regular cannabis use raises risk of psychosis

24 Apr 2019Registered users

Daily cannabis use is associated with a three-fold increased risk of psychotic disorder, a multicentre, international case-control study has shown.

Continuous ECG vs loop recording for AF detection post stroke

24 Apr 2019Registered users

Automatic external loop recording (ELR) is not suitable as a single monitoring device for AF screening following stroke, a prospective cohort study from Denmark has concluded.

SGLT2 inhibitor produces good glycaemic control in everyday practice

24 Apr 2019Registered users

An observational study from Scotland has shown that dapagliflozin produced equivalent improvements in glycaemic control in patients with type 2 diabetes in general practice to those reported in clinical trials.

Educational intervention encourages smokers to consult with respiratory symptoms

24 Apr 2019Registered users

Although an educational intervention increased respiratory consultations in smokers it did not improve detection of lung cancer, in a randomised controlled trial from Australia.

Alcohol use disorder affects offspring’s behaviour in adulthood

25 Mar 2019Registered users

Parental alcohol use disorder is associated with an increased likelihood of marriage to a spouse with alcohol use disorder, a Swedish population-based study has found. In particular, daughters of affected mothers were more likely to have an affected spouse.

Does intensive BP lowering reduce risk of dementia?

25 Mar 2019Registered users

Intensive blood pressure (BP) control reduces the risk of developing mild cognitive impairment, but not dementia, a US randomised trial has found.

Are e-cigarettes more effective than nicotine replacement therapy to help smokers quit?

25 Mar 2019Registered users

One year smoking cessation rates were significantly higher in those who used e-cigarettes compared with those using traditional nicotine replacement therapy (NRT) products, in a UK prospective study. However, many more of those on e-cigarettes who had quit ordinary cigarettes still used the substitute while most of those who quit using NRT were free from treatment.

Cuffless vs standard devices for ambulatory blood pressure monitoring

25 Mar 2019Registered users

A novel cuffless device recorded significantly higher values for both systolic and diastolic blood pressure (BP) compared with standard equipment for 24-hour ambulatory BP monitoring, in a small study from Switzerland.

Reminder app improves compliance with CHD therapy

22 Feb 2019Registered users

The use of a widely available basic medication reminder app significantly improved adherence to treatment for coronary heart disease (CHD), in a study from Australia.

Afternoon exercise more beneficial for blood glucose than morning exercise in type 2 diabetes

22 Feb 2019Registered users

A small but well designed pilot study from Scandinavia has suggested that afternoon exercise improves blood glucose in type 2 diabetes more effectively than exercise in the morning.

Deaths associated with opioid overdose increase

22 Feb 2019

A study from Ontario, Canada, has found that prescribed, diverted and illicit opioids all play an important role in the recent increase in opioid-related deaths.

Rise in vaping accompanied by fall in youth smoking

22 Feb 2019

An increase in the use of e-cigarettes (vaping) has been associated with a drop in smoking by teenagers and young adults, a time trend analysis from the United States has found.

Comparing incontinence rates following caesarean vs vaginal delivery of twins

23 Jan 2019Registered users

Urinary stress incontinence is more likely following vaginal than caesarean section (CS) delivery of twins, a multinational randomised controlled trial has shown.

What factors influence uptake of smoking in children?

23 Jan 2019Registered users

Living in a smoking household and having peers who smoke are key factors associated with children smoking, a cohort study has found. The investigators analysed data on 11,577 teenagers in the Millenium Cohort Study, a birth cohort of children born between September 2000 and January 2002 in the UK.

Type 1 diabetes in children is on the increase

23 Jan 2019Registered users

The incidence of childhood type 1 diabetes may double over the next two to three decades, findings from a multicentre European study suggest

Childhood trauma raises risk of drug misuse later on

23 Jan 2019Registered users

Individuals who suffer abuse as children are more likely to use marijuana or cocaine later in life, a study from the United States has found.

High BP, smoking and diabetes are stronger predictors of MI in women than men

20 Dec 2018Registered users

Hypertension, smoking, especially heavy smoking, and both type 1 and type 2 diabetes are associated with a higher risk of myocardial infarction (MI) in women than men, a prospective population-based study has shown.

Consumption of nitrate-cured meat products increases odds of mania

20 Dec 2018Registered users

There is a strong and independent association between manic episodes and a history of eating nitrate-cured meat products, a US study has found.

Orgasm induced by non sexual behaviour

20 Dec 2018Registered users

Orgasm may be a neuropsychological process associated with diverse forms of stimulation, according to the findings of a study published in the International Journal of Sexual Health. The investigators analysed comments from 919 individuals who responded to an anonymous post in 2013 on the website PostSecret.com. The individual, unknown to the research team, described having an orgasm during exercise. The respondents posted comments about their own experiences of non genital/non sexual orgasms.

Obesity in early childhood leads to obesity in adolescence

20 Dec 2018Registered users

The vast majority of children who were obese at three years of age were overweight or obese in adolescence, a study from Germany has found.

Non invasive skin autofluorescence test shows promise

20 Dec 2018Registered users

An immunofluorescence test may be able to predict new onset diabetes, cardiovascular disease (CVD) and death, a study from the Netherlands has shown.

AF recurrence following catheter ablation more likely in obese patients

22 Nov 2018Registered users

Atrial fibrillation (AF) patients with a baseline BMI = 30 kg/m2 have a higher recurrence rate following catheter ablation, a  study of  an AF Ablation Long-Term Registry that included 104 centres across 27 European countries.

Pre-eclampsia raises risk of vascular dementia later in life

22 Nov 2018Registered users

Women with a history of pre-eclampsia are three times more likely to develop vascular dementia later on, a Danish cohort study has found.

GP training programme improves HIV testing rates

22 Nov 2018Registered users

Sexual Health in Practice (SHIP), an educational programme tailored to general practice, increased GPs’ rates of HIV testing.

Risk factors for wheezing in early childhood across Europe

22 Nov 2018Registered users

Lower respiratory tract infections (LRTIs), maternal smoking, day care attendance and male gender are important risk factors for wheezing in infants, a panEuropean study has confirmed. Food allergy and infant feeding practices were not associated with wheeze. The prevalence of wheezing varied widely between different European countries.

Homelessness is an independent risk factor for mortality

01 Jun 2009Registered users

Although the higher mortality risk associated with homelessness can partly be explained by an increased prevalence of morbidity, homelessness itself confers an additional risk, a retrospective cohort study has shown. 'In this study, homelessness itself has been shown to be an independent risk factor for the high mortality seen in this group. In addition to interventions addressing morbidity in homeless people, intensive targeted social interventions directed to homelessness itself may be needed to lower mortality in this highly disadvantaged social group.'

Stroke risk similar in paroxysmal and sustained AF

23 Jan 2008Registered users

Current guidelines advise treating paroxysmal AF in the same way as sustained AF but the evidence is weak, with only one retrospective analysis comparing the risk of stroke in patients with paroxysmal AF vs chronic AF (analysis of the SPAF trials, performed 15 years ago and limited to patients treated with aspirin). The ACTIVE W trial showed that warfarin is more effective than aspirin plus clopidogrel for the prevention of vascular events (stroke, embolism, MI and vascular death) in patients with AF. A recent substudy of this trial looked at the risk of stroke in 1,202 patients with paroxysmal AF compared with 5,495 with sustained AF, and the effectiveness of thromboprophylaxis in these patients. ' This substudy has shown that the risk of stroke is similar, irrespective of whether AF is paroxysmal or sustained, and that anticoagulation therapy is equally effective in both groups. Other factors, such as age and cardiovascular comorbidity, remain central to the ultimate choice of thromboprophylaxis in these patients.'