Renal denervation plus a standardised stepped care antihypertensive treatment (SSAHT) regimen reduced ambulatory blood pressure more than the drug regimen alone in the DENERHTN triat. The study was a prospective, open-label randomised controlled trial with blinded endpoint evaluation in patients, aged 18-75 years, with resistant hypertension. It was carried out in 15 French tertiary care centres specialising in the management of hypertension.