Taddei RN, Aris A, Chaudhuri KR. Non-motor symptoms may herald Parkinson’s disease. Practitioner Dec 2017;261(1810):23-27

Non-motor symptoms may herald Parkinson’s disease

20 Dec 2017Registered users

While the three cardinal motor symptoms of Parkinson’s disease (PD), bradykinesia, rigidity and tremor, are key to the diagnosis of the condition, there is evidence that non-motor symptoms start long before motor features arise. Two of these in particular, REM sleep behaviour disorder and olfactory dysfunction, have been strongly associated with the development of PD. Non-motor symptoms are increasingly recognised as main features of PD with a high impact on quality of life. Their progression has been shown to be independent of motor deterioration. Sleep, GI and attention/memory problems become more prevalent over time, whereas psychiatric and cardiovascular problems become less prevalent.

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