Lithium reduces suicide risk in mood disorders. Practitioner 2013;257 (1764):10-11

Lithium reduces suicide risk in mood disorders

23 Sep 2013Pais-up subscribers

Lithium lowers the risk of suicide in both bipolar disorder and unipolar depression, a systematic review and meta-analysis has found. Overall, 48 randomised controlled trials, involving 6,674 participants, were included. Patients had a diagnosis of bipolar disorder (19 trials), unipolar depression (12 trials) or a mix of bipolar, unipolar or schizoaffective disorder (17 trials). They were randomised to receive either lithium, an active comparator or placebo over a period of at least three months.

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