Savill P. Fish oils show no benefit in patients with multiple CVD risk factors. Practitioner 2013; 257 (1762):7

Fish oils show no benefit in patients with multiple CVD risk factors

24 Jun 2013Registered users

Fish oils have no effect on cardiovascular morbidity and mortality in patients with multiple risk factors or atherosclerotic vascular disease, a large general practice-based study from Italy has found. The Risk and Prevention Study was double-blind and placebo-controlled. A total of 12,513 patients were enrolled who had multiple cardiovascular risk factors or atherosclerotic vascular disease but none had had a myocardial infarction (MI). They were followed up by a network of 860 GPs. Around half, 6,244 patients, were assigned to 1 g/day of n-3 fatty acids (polyunsaturated fatty acid ethyl esters with eicosapentaenoic acid and docosahexaenoic acid content not less than 85%) and 6,269 to placebo. The primary end point was initially a composite that included death, nonfatal MI and nonfatal stroke but was later revised at one year after a blinded assessment showed a very low event rate. The revised primary end point was death from cardiovascular causes or hospital admissions for cardiovascular problems. The median follow-up was five years.

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