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Bland P. Are antidepressants effective for back pain and osteoarthritis? Practitioner May 2021;265(1848):5

Are antidepressants effective for back pain and osteoarthritis?

25 May 2021Registered users

Serotonin-noradrenaline reuptake inhibitors (SNRIs) reduce both pain and disability in patients with low back pain and osteoarthritis (OA). However, the effect is small and not clinically relevant for back pain, although a clinically important effect for OA cannot be ruled out, a systematic review and meta-analysis has concluded.

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