A recent meta-analysis, published in JAMA, has suggested an increase in the risk of developing diabetes with high-dose statin therapy compared with moderate-dose therapy. However, the cardiovascular benefits appear to outweigh the risk of diabetes.The researchers analysed large, randomised controlled, hard end point studies that compared intensive with moderate-dose statin therapy and included more than 1,000 patients followed up for longer than a year. The trials studied in the meta-analysis were PROVE IT-TIMI 22, A to Z, TNT, IDEAL, and SEARCH. These five trials included 32,752 patients without diabetes mellitus at baseline.