Editorial

PSA at 60 may predict risk of death from prostate cancer - p5

Research reviews

Which common antidepressants are safest in overdose? - p7

Low glycaemic index diet reduces insulin resistance in polycystic ovary syndrome - p8

Do HRT patches increase the risk of stroke? - p8

Low vitamin D linked to depression in the elderly - p8-12

Can computers take sexual histories? - p12

Antiretroviral therapy reduces rates of HIV-1 transmission - p12-14

Symposium

Improving detection of colorectal cancer - p17-21

Managing acute and chronic pancreatitis - p23-27

Special Report

Be vigilant for secondary periprosthetic joint infection - p28-32

CPD

The Practitioner - CPD October 2010 - p33-34

Photoguide

Ulcerated lesions - p36-37

Haslam

Putting your stamp on general practice - p38