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= Paid-up subscribersAntiretroviral therapy reduces rates of HIV-1 transmission
20 Oct 2010
Giving antiretroviral therapy (ART) to patients with HIV-1 could reduce transmission rates in the population. The Partners in Prevention HSV/HIV Transmission Study enrolled heterosexual adults from seven African countries (Botswana, Kenya, Rwanda, South Africa, Tanzania, Uganda and Zambia) co-infected with HIV-1 and herpes simplex virus type 2 (HSV-2), along with their HIV-1 seronegative partners. The study was a randomised, double-blind, placebo-controlled trial of aciclovir HSV-2 suppressive therapy. A post-hoc analysis of data from this original study was undertaken with the aim of assessing the effect of ART use by HIV-1 infected participants on the risk of HIV-1 transmission to their uninfected partners. The majority of HIV infections in the world are due to HIV-1 which means these findings are still generalisable even though the study took place in Africa.
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